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A fully differential operational-amplifier used in a high gain ADC is designed．This op-amp adopts folded cascade to achieve high gain while the main op-amp uses gain-enhancement technique and switch capacitor common-mode feedback and the two auxiliary op-amps use continuous time common-mode feedback．In addition,it also uses the chopper stabilization,adding the chopper switch to the front and rear structures of the amplifier,so as to achieve the effect of filtering out the low-frequency noise. Based on SMIC 55nm,3.3V process,the simulation results show that the low-frequency noise of output noise is filtered out. the DC-gain of op-amp is 116.9dB,phase margin is 72°and unity-gain bandwidth is 355MHz,that can make the op-amp suitable for low-frequency domain and meet the needs of Sigma-Delta’s modulator design of audio domain．