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Because the traditional system has the problems of low accuracy and high false alarm rate, there is a great safety risk for vital signs monitoring of critically ill patients. According to the basic principle of the system architecture design, hardware structure, design of the sensor interface, alarm and command center set up monitoring component in monitoring; for the software part, extracting the signs, detection of Bluetooth and network connection status, collect and upload the information, and the remote command information receiving and display, and then realize the terminal design software interface. Through experimental verification, it is known that the system has high accuracy and low false alarm rate.