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For monitoring the real-time environment information including humidity, temperature, CO2 concentration in ICU, the real-time environment monitoring system in ICU has been designed. This system consists of environmental monitoring node in ICU, gateway node, the monitoring terminal. On the basis of CC2530, the software and the hardware of monitoring node have been designed. According to the characters of humidity, temperature, CO2 concentration in ICU, the drive circuit of each sensor module is designed. By using the Z-STACK, the software of monitoring node is designed to transmit the collected environment data. The test results show that reception rate of the gateway node is more than 80%, generation time of warning signals is less than three seconds and monitoring terminal has strong ability to refresh data. The system has characters of high accuracy、good real-time performance and timely warning.